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  • Title: Cytogenetic and comparative genomic hybridization studies of an esophageal giant fibrovascular polyp: a case report.
    Author: Yu Z, Bane BL, Lee JY, Pitha JV, Peyton M, Houck J, Li S.
    Journal: Hum Pathol; 2012 Feb; 43(2):293-8. PubMed ID: 21835434.
    Abstract:
    Esophageal giant fibrovascular polyps are rare and are thought to represent redundant tumorlike or hamartomatous esophageal folds. Although most patients present with slowly evolving dysphagia, a minority present with acute respiratory distress or even death caused by asphyxia. We present the pathologic and cytogenetic findings of an 18-cm esophageal giant fibrovascular polyp in a 49-year-old woman who presented with odynophagia and dysphagia. The histologic findings are that of classic esophageal giant fibrovascular polyp as previously described in the literature. Cytogenetic study revealed an abnormal karyotype, and comparative genomic hybridization analysis showed regional amplifications of chromosomes 3 and 12 and a possible loss of 22q13.3-qter. The significance of these cytogenetic findings is unclear but may suggest a neoplastic process in the pathogenesis of esophageal giant fibrovascular polyps.
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