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  • Title: [Oral propranolol in the management of periorbital proliferating phase infantile hemangioma].
    Author: Zhao ZF, Lü RR, Zhang J, Huo R, Xu GQ, Fu HB, Guo X, Wui JC, Lin LL.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2011 May; 27(3):174-7. PubMed ID: 21837994.
    Abstract:
    OBJECTIVE: To observe the efficacy and safety of oral propranolol in the treatment of periorbital proliferating phase infantile hemangioma. METHODS: A retrospective review of patient medical records was performed. 12 patients (9 female, 3 male; 1.5-8.5 months, average 3.3 months) with periorbital proliferating phase infantile hemangioma underwent oral propranolol therapy. The dosage was slowly increased to 2 mg/kg daily in divided doses for a mean duration of 16 weeks (range 4 weeks-41 weeks). Therapeutic outcomes and safety were established by evaluating colour, size of lesion, duration of treatment and side-effects of treatment before and after treatment. RESULTS: Of these, 9 had a signification reduction in colour and size of the lesions, 2 had no further growth. 1 is stopped therapy due to hypotension after drug administration. 11 other patients, although mild adverse effects were noted, no symptoms were severe enough to discontinue treatment. CONCLUSIONS: Propranolol appears to be a safe and effective treatment in the management of periorbital proliferating phase infantile hemangioma.
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