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  • Title: Solubilisation of griseofulvin and rutin in aqueous micellar solutions of gemini and heterogemini surfactants and their mixtures.
    Author: Lukáč M, Prokipčák I, Lacko I, Devínsky F.
    Journal: Eur J Pharm Sci; 2011 Oct 09; 44(3):194-9. PubMed ID: 21839832.
    Abstract:
    The solubilisation of two natural compounds, griseofulvin and rutin, in micellar solutions of mixtures of gemini (N,N'-didecyl-N,N,N',N'-tetramethylethane-1,2-diyldiammonium dibromide) and heterogemini (decyl 2-[decyl(dimethyl)ammonio]ethylphosphate) surfactants has been studied. The highest solubilisation capacities were found for mixtures with a molar fraction of heterogemini surfactant equal or greater than the molar fraction of gemini surfactant. The relationship between synergism in surface properties of mixtures of surfactants and their solubilisation properties was also investigated.
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