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  • Title: Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.
    Author: Cumpstey I, Ramstadius C, Eszter Borbas K, Alonzi DS, Butters TD.
    Journal: Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5219-23. PubMed ID: 21840710.
    Abstract:
    Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.
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