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  • Title: Clinicopathologic insight of simultaneously detected primary endometrial and ovarian carcinomas.
    Author: Rodolakis A, Thomakos N, Akrivos N, Sotiropoulou M, Ioannidis I, Haidopoulos D, Vlachos G, Antsaklis A.
    Journal: Arch Gynecol Obstet; 2012 Mar; 285(3):817-21. PubMed ID: 21842403.
    Abstract:
    PURPOSE: To evaluate the clinicopathologic features in patients with synchronous primary carcinomas of the ovary and endometrium. METHODS: Clinical information and pathologic details were collected and analyzed from 30 women with synchronous endometrial and ovarian cancers. RESULTS: Median age at diagnosis was 51 years. Abnormal uterine bleeding was the most common presenting symptom (50%). More than half (53%) of the patients were premenopausal and 37% never had a pregnancy. Stage I disease was observed in 90 (27/30) and 73% (22/30) of the patients with endometrial and ovarian cancer, respectively. Endometrioid type was the most frequently observed histology for synchronous endometrial and ovarian cancer (n = 18/30, 60%). All patients were surgically staged and adjuvant treatment was considered when required according to our protocols. The mean follow-up period was 6.6 years (SD = 3.0 years), and the cumulative event-free rate for 5 years was 84.2% (SE 7.3%). No significant differences in the survival rates were found according to the histological subtype (p = 0.513). Women with synchronous primary cancers of the endometrium and ovary were generally younger than those developing either one of the above mentioned adenocarcinomas. They appeared to have a favorable prognosis with an estimated overall survival of 84.2% in 5 years. CONCLUSIONS: A gynecologist should always keep in mind the possibility of double primary carcinomas of the endometrium and ovary in a young, premenopausal, nulliparous woman presenting with abnormal uterine bleeding and prompt the patient for further evaluation.
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