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  • Title: Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder.
    Author: Bae KY, Kim DW, Im CH, Lee SH.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 2011 Dec 01; 35(8):1908-17. PubMed ID: 21843580.
    Abstract:
    OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relationship with symptom severity. METHODS: ERPs were recorded in 30 PTSD patients and 33 healthy controls while participants were performing the auditory oddball task. We compared P300 current source density data--obtained by standardized low-resolution brain electromagnetic tomography (sLORETA)--between the two groups. The correlation between P300 current source density and clinical symptoms (as evaluated using the Korean version of the Structured Interview for PTSD--K-SIPS and Davidson Trauma Scale--K-DTS) was conducted. RESULTS: In PTSD patients, the current source density of P300 is significantly reduced in the inferior frontal gyrus, precentral gyrus, insula, and anterior cingulate compared to healthy controls. Total K-DTS scores were correlated with the P300 current source density in the posterior cingulate gyrus. The K-SIP B items (re-experiencing) and K-SIB D items (increased arousal) were positively correlated with P300 current source densities in several brain regions located in the frontal, parietal, and temporal lobe (p<0.05). Conversely, the K-SIP C items (avoidance and numbing) were negatively correlated with P300 current source densities in the superior and middle frontal gyri in the frontal lobes (p<0.05). CONCLUSION: The P300 current source densities reflected the pathophysiology of PTSD patients. PTSD symptoms were related to different neural activities, depending on their symptom characteristics.
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