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  • Title: Treatment of status epilepticus with plasmapheresis in a patient with thrombotic thrombocytopenic purpura.
    Author: Bilgir O, Bilgir F, Calan M, Kebapcilar L, Pamuk B, Yuksel A.
    Journal: Transfus Apher Sci; 2011 Oct; 45(2):149-50. PubMed ID: 21843973.
    Abstract:
    Thrombotic thrombocytopenic purpura (TTP) is a syndrome with numerous neurological manifestations including altered mental status and seizures. However, status epilepticus (SE) has rarely been reported in this condition. Signs may be transient or fluctuate; however, permanent deficits do occur. Its prognosis was once considered uniformly poor, with a high mortality rate. Since the introduction of plasma infusions and exchanges, the prognosis of the disease has improved dramatically; remissions now occur in 80-90% of patients. Altered mental status in TTP often resolves with plasmapheresis. Likewise, we successfully treated a patient with thrombotic thrombocytopenic purpura (TTP) with pronounced clinical effects of status epilepticus with plasmapheresis and steroid treatment.
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