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  • Title: Pharmacological management of type 2 diabetes mellitus: an update.
    Author: El-Kaissi S, Sherbeeni S.
    Journal: Curr Diabetes Rev; 2011 Nov; 7(6):392-405. PubMed ID: 21846326.
    Abstract:
    While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.
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