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  • Title: Wegener's granulomatosis mimicking skull base osteomyelitis.
    Author: Sharma A, Deshmukh S, Shaikh A, Dabholkar J.
    Journal: J Laryngol Otol; 2012 Feb; 126(2):203-6. PubMed ID: 21846420.
    Abstract:
    OBJECTIVE: To report a case of Wegener's granulomatosis mimicking skull base osteomyelitis. CASE REPORT: A case of Wegener's granulomatosis is reported in a diabetic woman presenting with facial palsy and hearing loss. The clinical course of the disease was very similar to that of skull base osteomyelitis, especially since the patient was diabetic and the ear swab was positive for pseudomonas. The definitive diagnosis was made based on clinical presentation, imaging and serum antineutrophil cytoplasmic antibody testing. The patient was started on immunosuppressants, and her hearing loss and facial palsy recovered. CONCLUSION: Wegener's granulomatosis is a systemic disease with various manifestations. A high index of clinical suspicion is required to reach the correct diagnosis. The clinician should be alerted to the possibility of Wegener's granulomatosis in the presence of: systemic upset out of proportion to the apparent intensity of the local lesion; middle-ear disease failing to respond to conventional treatment; and a consistently raised erythrocyte sedimentation rate.
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