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  • Title: Role of immunity to mycobacterial stress proteins in rheumatoid arthritis.
    Author: McLean L, Winrow V, Blake D.
    Journal: J Exp Pathol (Oxford); 1990 Apr; 71(2):295-303. PubMed ID: 2184873.
    Abstract:
    'Stress Proteins in Inflammation' provided a forum for the discussion of topical issues in this rapidly moving field. The mycobacterial 65 kDa stress proteins play a key role in certain animal models of inflammatory arthritis. However, the impression emerging is that the mechanism probably involves more than a simple cross-reaction between mycobacterial SP65 and either the host SP65 or a cartilage antigen, and that evidence for a primary role in human rheumatoid arthritis is lacking. A realistic role for immune responses against stress proteins might be the amplification or perpetuation of inflammation. If so, this is unlikely to be limited to arthritis.
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