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  • Title: The effects of ibuprofen on sepsis parameters in preterm neonates.
    Author: Demirel G, Celik IH, Canpolat FE, Erdeve O, Oguz SS, Dilmen U.
    Journal: Early Hum Dev; 2012 Apr; 88(4):195-6. PubMed ID: 21849239.
    Abstract:
    AIM: To examine the effects of ibuprofen used for patent ductus arteriosus (PDA) treatment on the production of the proinflammatory cytokines C-reactive protein (CRP) and interleukin 6 (IL-6) in preterm septic newborns. METHODS: Patients with acute phase reactant elevation were divided into two groups according to receiving ibuprofen (Group I, n=51) or not (Group II, n=38). Course of sepsis was evaluated by CRP and IL-6 levels. RESULTS: CRP and IL-6 levels at the time of diagnosis were not different between two groups [16±9.1 vs 16.4±13.2mg/dL (p=0.43) for CRP and 124±82 vs 119±73mg/dL (p=0.517) for IL-6, respectively]. Similarly, they were statistically insignificant between the groups at the 2nd or 3rd days of ibuprofen treatment [14.3±7.7 vs 13.7±5.9mg/dL (p=0.21) for CRP and 83±46 vs 86±37mg/dL (p=0.29) for IL-6, respectively]. However, CRP and IL6 levels showed significant difference between groups in the following days; 6.03±3.8 vs 9.1±4.9mg/dL (p=0.025) for CRP and 42±33.1 vs 58.9±27.1mg/dL (0.011) for IL-6 on 4th or 5th days of treatment and 2.3±3.2 vs 4.1±2.3mg/dL (p=0.032) for CRP and 16.1±12.4 vs 21.3±16.8mg/dL (p=0.016) for IL-6, on 7th to 10th days of treatment, respectively. CONCLUSIONS: IL-6 and CRP may decrease in infants receiving ibuprofen treatment more than infants who do not receive it. This decrease should be considered at the time of caring a preterm infant with both sepsis and PDA after ibuprofen treatment.
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