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  • Title: Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents.
    Author: Alafeefy AM, Ashour AE.
    Journal: J Enzyme Inhib Med Chem; 2012 Aug; 27(4):541-5. PubMed ID: 21851213.
    Abstract:
    Twenty-two quinazoline derivatives have been synthesised and examined for their anti-tumour activity against three tumour cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatoma cell line (HepG2). Twelve of the tested compounds have shown promising anti-tumour activity with an IC(50) range of 5.0-9.7 µg/mL. Regarding the spectrum of activity, five compounds exhibited interesting anti-proliferative properties against the three tested cell lines comparable to the reference drug (dasatinib).
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