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  • Title: Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy.
    Author: Zhu X, Lu W, Zhang Y, Reed A, Newton B, Fan Z, Yu H, Ray PC, Gao R.
    Journal: Chem Commun (Camb); 2011 Oct 07; 47(37):10311-3. PubMed ID: 21853198.
    Abstract:
    5,10,15,20-Tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin produced twice as many singlet oxygen ((1)O(2)) molecules at pH 5.0 (quantum yield 0.53 ± 0.01) than at pH 7.4, whereas the (1)O(2) quenching rate was reduced by a factor of 2.5 for a pH change from 7.4 to 5.0.
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