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  • Title: [Liver fibrosis and cirrhosis--causes. Part I].
    Author: Wirkowska A, Paczek L.
    Journal: Przegl Lek; 2011; 68(4):222-7. PubMed ID: 21853678.
    Abstract:
    Liver fibrosis is one of the most compound pathological process occurred as the answer to risen inflammation factor. It is characterized by balance disorders between syntesis and degradation ECM (Extracellular Matrix) by myofibroblasts. This appears when activated by inflammation factor HSC cells transform in myofibroblasts. Among major causes of the chronic liver inflammation, with parenchymal cells destruction and replace of connective tissue, are: hepatotropic viruses (HCV, HBV), alcohol, autoimmunologic disorders.
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