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  • Title: Palladium-catalyzed alkylation of ortho-C(sp2)-H bonds of benzylamide substrates with alkyl halides.
    Author: Zhao Y, Chen G.
    Journal: Org Lett; 2011 Sep 16; 13(18):4850-3. PubMed ID: 21853967.
    Abstract:
    A highly efficient and generally applicable method has been developed to functionalize the ortho-C(sp(2))-H bonds of picolinamide (PA)-protected benzylamine substrates with a broad range of β-H-containing alkyl halides. Sodium triflate has been identified as a critical promoter for this reaction system. The PA group can be easily installed and removed under mild conditions. This method provides a new strategy to prepare highly functionalized benzylamines for the synthesis of complex molecules.
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