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  • Title: Coverage of full-thickness burns with bilayered skin equivalents: a preliminary clinical trial.
    Author: Hull BE, Finley RK, Miller SF.
    Journal: Surgery; 1990 May; 107(5):496-502. PubMed ID: 2185567.
    Abstract:
    A total of six patients have received bilayered skin-equivalent coverage of full-thickness burns, with takes of 50% to 70% in the later patients. These skin-equivalent grafts are constructed by combining allogeneic fibroblasts with collagen to form a sheet and adding a suspension of autologous epidermal cells to the surface of the collagen matrix. These bilayered skin-equivalent grafts have provided an expansion of at least fifteenfold to twentyfold for the area covered by the donor epidermis. By 8 months after grafting, the skin-equivalent grafts appeared smooth and approximated the color of normal skin. Long-term problems associated with hypertrophic scarring or graft fragility have not developed during the 18-month period of follow-up.
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