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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: [Disulfiram implants. Lack of pharmacological and clinical effects].
    Author: Johnsen J, Mørland J.
    Journal: Tidsskr Nor Laegeforen; 1990 Apr 10; 110(10):1229-30. PubMed ID: 2185582.
    Abstract:
    The therapeutic rationale for using implanted disulfiram is possible inhibition of the liver enzyme acetaldehyde dehydrogenase, producing an acetaldehyde-mediated aversive reaction after intake of ethanol. Several studies using volunteers and patients in a double blind controlled study produced no evidence that a disulfiram implant (1 g) has any significant pharmacological or clinical action, except for a higher frequency of local surgical complications.
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