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  • Title: Synchronous epithelial and neuroendocrine cancers of the pancreas: case series of a rare occurrence.
    Author: Power DG, Shia J, Allen PJ, Jarnagin WR, O'Reilly EM.
    Journal: Clin Colorectal Cancer; 2011 Jun; 10(2):146-50. PubMed ID: 21859569.
    Abstract:
    The presence of neuroendocrine cells in adenocarcinomas is not an unusual finding and is well described in gastrointestinal tract cancers, eg, colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenitor stem cell origin. The prognostic significance of neuroendocrine cells in adenocarcinoma cells is unclear. There is a scant literature on synchronous pancreas ductal adenocarcinoma and pancreas neuroendocrine tumors. We report 2 cases with a purpose of discussing management strategies, prognosis, and potential etiologies of this rare presentation.
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