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  • Title: Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae).
    Author: Lúcio AS, Almeida JR, Barbosa-Filho JM, Pita JC, Branco MV, Diniz Mde F, Agra Mde F, da-Cunha EV, da Silva MS, Tavares JF.
    Journal: Molecules; 2011 Aug 22; 16(8):7125-31. PubMed ID: 21860364.
    Abstract:
    Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively.
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