These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [FABP2 gene polymorphism and metabolic disorder of lipids in the middle aged and aged population].
    Author: Liu Y, Zhai C, Cao P, Zheng Y, Zhou S, Chi J.
    Journal: Wei Sheng Yan Jiu; 2011 Jul; 40(4):461-4. PubMed ID: 21861348.
    Abstract:
    OBJECTIVE: To learn the gene distribution of fatty acid binding protein gene (FABP2) and the mutation frequency of wild type A54T in FABP2 gene in the people with abnormal lipid metabolism to detect from molecular level the relationship between FABP2 gene polymorphism and metabolic disorder of lipids, and to investigate genetic factors and the pathogenesis of lipid metabolic disorders in the middle aged and aged people. METHODS: The polymorphism of FABP2 gene was analyzed by RELP (Restriction fragment length polymorphism) technique. The relationship between FABP2 polymorphism and the risk of dyslipidemia in 410 middle aged and aged people was investigated. RESULTS: Mutation frequency of FABP2 gene in the people with dyslipidemia was 71.9%, significantly higher than that in the people with normal blood lipids (P < 0.05). Compared with individuals with wild type homozygote (Ala54/Ala54), the serum TC and TG of individuals with mutational heterozygote (Ala54/Thr54) or mutational homozygote (Thr54/Thr54) were distinctly higher, and serum HDL-C of them were distinctly lower (P < 0.05). CONCLUSION: FABP2 gene polymorphism might be one of factors for genetic susceptibility in metabolic disorder of lipids. The risk of occurring lipid metabolic disorders in individuals carrying mutational FABP2 gene (Ala54/Thr54, Thr54/Thr54) might be higher than those carrying wild type homozygote (Ala54/ Ala54) while exposed to the same environment.
    [Abstract] [Full Text] [Related] [New Search]