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  • Title: Improving the use of allopurinol in chronic gout: monitoring oxypurinol levels to guide therapy.
    Author: Keith MP, Gilliland WR.
    Journal: Clin Pharmacol Ther; 2011 Sep; 90(3):363-4. PubMed ID: 21862966.
    Abstract:
    Urate-lowering therapy (ULT), adjusted to achieve and maintain a serum uric acid (SUA) of <6 mg/dl, remains the standard of care for the chronic management of gout. New urate-lowering medications are important options; however, these agents should be reserved for patients who do not tolerate or cannot achieve SUA <6 mg/dl on allopurinol. The result of oxypurinol monitoring to guide allopurinol therapy suggests that allopurinol should still be considered first-line ULT for gout.
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