These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chiral phosphoproline-catalyzed asymmetric Michael addition of ketones to nitroolefins: an experimental and theoretical study.
    Author: Zeng Z, Luo P, Jiang Y, Liu Y, Tang G, Xu P, Zhao Y, Blackburn GM.
    Journal: Org Biomol Chem; 2011 Oct 21; 9(20):6973-8. PubMed ID: 21863184.
    Abstract:
    A novel pyrrolidine-based chiral phosphoproline is an effective bifunctional organocatalyst for the asymmetric Michael addition of ketones to nitroolefins giving high levels of diastereo- and enantio-selectivities (up to > 99 : 1 dr and 96% ee). anti-SR Transition state has the lowest barrier which controls the stereoselectivity, in agreement with experimental results.
    [Abstract] [Full Text] [Related] [New Search]