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  • Title: Three-step synthesis of cyclopropyl peptidomimetics.
    Author: Dunlap N, Lankford KR, Pathiranage AL, Taylor J, Reddy N, Gouger D, Singer P, Griffin K, Reibenspies J.
    Journal: Org Lett; 2011 Sep 16; 13(18):4879-81. PubMed ID: 21863816.
    Abstract:
    An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.
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