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  • Title: [Sucralfate: the agent of choice in the treatment of peptic ulcer?].
    Author: Fedorov NE, Laktionova AA, Tkachev AV, Iakovlev AA, Soboleva LV, Grib VM.
    Journal: Ter Arkh; 1990; 62(2):64-7. PubMed ID: 2186496.
    Abstract:
    As many as 72 patients with erosive and ulcerous injuries to the stomach and duodenum were examined for the clinical efficacy of antepsin (sucralfate). Of these patients, 42 were with duodenal ulcer, 10 with gastric ulcer and 20 with erosive gastroduodenitis). Antepsin exerted a beneficial effect on the painful syndrome and on ulcer and erosion healing. The coefficient of the therapeutic efficacy of antepsin in duodenal ulcer patients turned out to be equal to 2.67 that of gastric ulcer to 2.1 and that in patients with gastroduodenitis was 2.6. The drug did not produce any well-defined side effects. In some cases (8.3%), it caused the appearance or enhancement of constipation. Antepsin is indicated not only in ulcer disease but also in duodenogastric reflux, reflux gastritis and reflux esophagitis.
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