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  • Title: Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.
    Author: Reina E, Puentes C, Rojas J, García J, Ramos FA, Castellanos L, Aragón M, Ospina LF.
    Journal: Bioorg Med Chem Lett; 2011 Oct 01; 21(19):5888-91. PubMed ID: 21865038.
    Abstract:
    The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5-10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute stereochemistry was determined by chiroptical methods. Fuscoside E (1) and B (2) showed strong anti-inflammatory in the above mentioned bioassay. Additionally, fuscoside E (1) and the sterol mixture (5-10) presented antifouling activity against bacterial strains involved in surface colonization.
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