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  • Title: Synthesis and pharmacological screening of new angiotensin converting enzyme inhibitors.
    Author: Gubert S, Braso MA, Sacristán A, Ortiz JA.
    Journal: Farmaco; 1990 Jan; 45(1):59-79. PubMed ID: 2186741.
    Abstract:
    We report the preparation of a series of eight L-alanyl-L-proline derivatives and four L-proline derivatives. Their pharmacological activity as antihypertensive agents was examined with reference to changes in the contractile response to angiotensin I (AI), bradykinine (BK) and angiotensin II (AII). Compounds 1g, 1h and 2c were the most powerful when compared with known angiotensin-converting inhibitors such as captopril and enalapril, and were selected for further pharmacological study.
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