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  • Title: [Amiodarone and thyroid: the Janus effect].
    Author: Unger J.
    Journal: Rev Med Brux; 1990 Apr; 11(4):89-95. PubMed ID: 2187219.
    Abstract:
    Iodide released from Amiodarone during a chronic treatment is 100 x higher than food iodide intake. Thyroid adaptation allows normal function but over-adaptation leads to hypothyroidism and hypo-adaptation to thyrotoxicosis. Thyrotoxicosis may also result from follicular disruption. Amiodarone inhibits 5' deiodinase type I and II and hence increases serum T4 and (transiently) TSH and decreases serum T3 concentrations. Perchlorate and corticoids may be useful in the treatment of thyrotoxicosis.
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