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  • Title: Temporal relationships of a pulse of prolactin (PRL) to a pulse of a metabolite of PGF2α in mares.
    Author: Ginther OJ, Pinaffi FL, Silva LA, Beg MA.
    Journal: Theriogenology; 2012 Jan 01; 77(1):99-107. PubMed ID: 21872321.
    Abstract:
    Hourly blood samples were collected from 10 mares during 24 h of each of the preluteolytic, luteolytic, and postluteolytic periods. The autocorrelation function of the R program was used to detect pulse rhythmicity, and the intra-assay CV was used to locate and characterize pulses of prolactin (PRL) and a metabolite of prostaglandin F2α (PGFM). Rhythmicity of PRL and PGFM concentrations was detected in 67% and 89% of mares, respectively. Combined for the three periods (no difference among periods), the PRL pulses were 5.2±0.4 h (mean±SEM) at the base, 7.5±1.5 h between nadirs of adjacent pulses, and 12.3±1.5 h from peak to peak. The peaks of PRL pulses were greater (P<0.05) during the luteolytic period (46±14 ng/mL) and postluteolytic period (52±15 ng/mL) than during the preluteolytic period (17±3 ng/mL). Concentrations of PRL during hours of a PGFM pulse were different (P<0.003) within the luteolytic period and postluteolytic period and were greatest at the PGFM peak; PRL concentrations during a PGFM pulse were not different during the preluteolytic period. The frequency of the peak of PRL and PGFM pulses occurring at the same hour (synchrony) was greater for the luteolytic period (65%, P<0.01) and postluteolytic period (50%, P<0.001) than for the preluteolytic period (17%). This is the first report in mares on characterization and rhythmicity of PRL pulses, synchrony between PRL and PGFM pulses, and greater PRL activity during the luteolytic and postluteolytic periods than during the preluteolytic period.
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