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  • Title: Nickel-catalyzed chelation-assisted transformations involving ortho C-H bond activation: regioselective oxidative cycloaddition of aromatic amides to alkynes.
    Author: Shiota H, Ano Y, Aihara Y, Fukumoto Y, Chatani N.
    Journal: J Am Chem Soc; 2011 Sep 28; 133(38):14952-5. PubMed ID: 21875095.
    Abstract:
    Although the pioneering example of ortho metalation involving cleavage of C-H bonds was achieved using a nickel complex (Kleiman, J. P.; Dubeck, M. J. Am. Chem. Soc. 1963, 85, 1544), no examples of catalysis using nickel complexes have been reported. In this work, the Ni-catalyzed transformation of ortho C-H bonds utilizing chelation assistance, such as oxidative cycloaddition of aromatic amides with alkynes, has been achieved.
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