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  • Title: Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet's disease.
    Author: Vural B, Uğurel E, Tüzün E, Kürtüncü M, Zuliani L, Cavuş F, Içöz S, Erdağ E, Gül A, Güre AO, Vincent A, Ozbek U, Eraksoy M, Akman-Demir G.
    Journal: J Neuroimmunol; 2011 Oct 28; 239(1-2):91-7. PubMed ID: 21875754.
    Abstract:
    No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.
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