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  • Title: Evaluation of the microvascularization of pathologic parathyroid glands in patients with primary hyperparathyroidism using conventional ultrasound and contrast-enhanced ultrasound.
    Author: Uller W, Jung EM, Hornung M, Ross C, Jung W, Schlitt HJ, Stroszczynski C, Agha A.
    Journal: Clin Hemorheol Microcirc; 2011; 48(1):95-103. PubMed ID: 21876238.
    Abstract:
    PURPOSE: The objective was to characterize the microcirculation of parathyroid adenomas using contrast-enhanced ultrasound (CEUS) and to evaluate if it can be used for diagnosis and localization of pathologic glands. PATIENTS AND METHODS: Thirty patients with primary hyperparathyroidism scheduled for parathyroidectomy were enrolled. Preoperatively, all patients underwent B-Scan sonography, Colour coded Doppler Sonography (CCDS), Power Doppler (PD) and CEUS. The diagnostic confidence concerning B-Scan, CCDS, PD and CEUS was classified into six grades (0: no adenoma; 5: adenoma). RESULTS: Using CEUS, all adenomatous glands showed a typical dynamic microvascularization. B-Scan showed a mean grade of 2.18, CCDS 2.29, PD 2.33, CEUS 4.29 (6-9 MHz transducer) and 3.52 (6-15 MHz). The differences between CEUS and conventional sonography were all statistically significant (p < 0.05). CEUS noted a sensitivity of 98.4% and specificity of 98.4% for the detection of adenomatous glands. CONCLUSION: CEUS facilitates the detection and diagnosis of pathologic parathyroid glands due to their typical microvascularization.
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