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  • Title: Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia.
    Author: Ito C, Itoigawa M, Nakao K, Murata T, Kaneda N, Furukawa H.
    Journal: J Nat Med; 2012 Apr; 66(2):357-61. PubMed ID: 21879331.
    Abstract:
    We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.
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