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  • Title: Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.
    Author: Devji T, Reddy C, Woo C, Awale S, Kadota S, Carrico-Moniz D.
    Journal: Bioorg Med Chem Lett; 2011 Oct 01; 21(19):5770-3. PubMed ID: 21880488.
    Abstract:
    A series of hydroxycoumarin derivatives has been synthesized and evaluated against human pancreatic PANC-1 cancer cells under nutrient-deprived conditions. Several compounds exhibited 100% preferential cytotoxicity at low micromolar concentrations under nutrition starvation, and showed no cytotoxicity under nutrient-rich conditions. In this study, a novel geranylgeranylated ether coumarin derivative 9 was found to exhibit the highest cytotoxic activity of 6.25 μM within 24h. The preferential anti-tumor activity exhibited by compound 9 against PANC-1 under low oxygen and nutrient environment illustrates its great potential as a promising lead structure for the development of novel agents to combat pancreatic cancer.
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