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  • Title: [Locally advanced cervical cancer: Should intensity-modulated radiotherapy replace brachytherapy?].
    Author: Mazeron R, Gilmore J, Khodari W, Dumas I, Haie-Méder C.
    Journal: Cancer Radiother; 2011 Oct; 15(6-7):477-83. PubMed ID: 21880534.
    Abstract:
    Intensity-modulated conformal radiotherapy (IMRT) is booming as treatment of locally advanced cervical cancer. This technique reduces the doses delivered to organs at risk and, by analogy to the irradiation of prostate cancer, opens the door to the possibility of dose escalation to levels close or similar to those achieved by brachytherapy. To date, several studies comparing IMRT with brachytherapy have been published, often methodologically flawed, concluding sometimes that both techniques are comparable. These results should be taken with extreme caution and should not overshadow the recent advances in brachytherapy with the use of 3D imaging and optimization. Preliminary works also showed that the combination of 3D optimized brachytherapy with IMRT could improve the management of the local disease especially for lesions poorly covered by intracavitary techniques.
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