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  • Title: MCP-1 and CCR2 gene variants in oral squamous cell carcinoma.
    Author: Bektas-Kayhan K, Unur M, Boy-Metin Z, Cakmakoglu B.
    Journal: Oral Dis; 2012 Jan; 18(1):55-9. PubMed ID: 21883707.
    Abstract:
    AIM: We aimed to investigate a possible association of the MCP-1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC). METHODS: MCP-1 A2518G and CCR2 V64I gene polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism, in 129 patients with OSCC and 140 healthy control subjects. RESULTS: Individuals who had G allele and GG genotype of MCP-1, and 64I allele and wt/64I genotype of CCR2 had increased risk for OSCC (P<0.05.) In contrast, individuals with CCR2 wt/wt genotype seem to be protected from OSCC (P < 0.01). Haplotype analysis revealed that MCP-1G: CCR2 64I haplotype frequencies were significantly higher in patients than those of controls (P = 0.001). CONCLUSIONS: We can suggest that the G allele of MCP-1 and 64I allele of CCR2 may be risk factors for OSCC.
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