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  • Title: Geographic tongue treated with topical tacrolimus.
    Author: Ishibashi M, Tojo G, Watanabe M, Tamabuchi T, Masu T, Aiba S.
    Journal: J Dermatol Case Rep; 2010 Dec 31; 4(4):57-9. PubMed ID: 21886753.
    Abstract:
    BACKGROUND: Geographic tongue, or benign migratory glossitis, is usually an asymptomatic inflammatory disorder of the tongue mucosa of unknown etiology. It is characterized by circinate, erythematous, ulcer-like lesions of the dorsum and lateral border of the tongue due to loss of filiform papillae of the tongue epithelium. Symptomatic treatments have not been evaluated rigorously. MAIN OBSERVATION: We describe herein two cases of adult patients with persistent and painful geographic tongue successfully treated with topical application of 0.1% tacrolimus ointment. CONCLUSION: To our knowledge, this is the first report of successful treatment with topical 0.1% tacrolimus for symptomatic geographic tongue. Clinical trials are needed to confirm the efficacy and the safety of topical tacrolimus in treating geographic tongue.
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