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  • Title: Click-chemistry approach to isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates.
    Author: Vorobyeva DV, Karimova NM, Odinets IL, Röschenthaler GV, Osipov SN.
    Journal: Org Biomol Chem; 2011 Nov 07; 9(21):7335-42. PubMed ID: 21887453.
    Abstract:
    A convenient strategy for the synthesis of isoxazole-containing α-CF(3)-substituted α-aminocarboxylates and α-aminophosphonates have been developed. The method is based on copper-catalyzed 1,3-dipolar cycloaddition of different aromatic nitrile oxides to functionalized acetylenes.
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