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  • Title: Total synthesis of oxazolomycin A.
    Author: Eto K, Yoshino M, Takahashi K, Ishihara J, Hatakeyama S.
    Journal: Org Lett; 2011 Oct 07; 13(19):5398-401. PubMed ID: 21888385.
    Abstract:
    The first total synthesis of oxazolomycin A, a structurally novel oxazole polyene γ-lactam/β-lactone antibiotic, is described. Key features include the stereocontrolled construction of the right-hand heterocyclic core by taking advantage of an In(III)-catalyzed Conia-ene type cyclization and the asymmetric synthesis of the left-hand segment starting with a Cinchona alkaloid-catalyzed cyclocondensation of an aldehyde with an acid chloride.
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