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  • Title: Design and synthesis of inhibitors of noroviruses by scaffold hopping.
    Author: Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC.
    Journal: Bioorg Med Chem; 2011 Oct 01; 19(19):5749-55. PubMed ID: 21893416.
    Abstract:
    A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.
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