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  • Title: [An extremely high serum methotrexate concentration associated with acute renal failure in a patient with acute lymphoblastic leukemia after conduction of high dose consolidation].
    Author: Pimenova MA, Sokolov AN, Biriukova LS, Ustinova EN, Shaforostova II, Donskova IA, Bogdanov RF, Parovichnikova EN, Savchenko VG.
    Journal: Ter Arkh; 2011; 83(7):58-61. PubMed ID: 21894753.
    Abstract:
    Acute renal failure (ARF) is one of rare and severe methotrexate (MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extracorporeal MT elimination. The presence of homozygous mutation of methylene-tetrahydrofolate reductase reflects an individual metabolism of MT and its renal clearance.
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