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  • Title: Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance.
    Author: Li Z, Cheng E, Huang W, Zhang T, Yang Z, Liu D, Tang Z.
    Journal: J Am Chem Soc; 2011 Oct 05; 133(39):15284-7. PubMed ID: 21894982.
    Abstract:
    A novel strategy of dual steric hindrance, which was obtained by Janus modification of gold nanoparticles (Au NPs) and volume exclusion of DNA, was adopted to prepare mono-DNA-modified Au NPs. The yield of mono-DNA-functionalized Au NPs significantly improved from 44 to 70% in the reaction between Au NPs and thiolated DNA. Furthermore, the specificity of mono-DNA-functionalized Au NPs was enhanced from 57 to 95%. The as-prepared Au NPs without postsynthetic treatment showed good controllability in self-assembly fabrication of complex nanostructures.
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