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  • Title: Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
    Author: de Freitas Pires A, Assreuy AM, Lopes ÉA, Celedônio NR, Soares CE, Rodrigues NV, Sousa PL, Benevides RG, Nagano CS, Cavada BS, Leal-Cardoso JH, Coelho-de-Souza AN, Santos CF.
    Journal: Fundam Clin Pharmacol; 2013 Apr; 27(2):201-9. PubMed ID: 21895762.
    Abstract:
    The objective of this study was to evaluate the antinociceptive effects of a lectin from Canavalia brasiliensis (ConBr) when administered orally to murine models of chemical and thermal nociception. ConBr up to 100 mg/kg produced significant and dose-dependent antinociceptive effects: 81% reduction in abdominal writhing induced by 0.6% acetic acid; 26 and 52% reduction in early- and late-stage paw licking, respectively, induced by 2.5% formalin; and 155% increase in reaction latency (heightened thermal pain threshold). In all models, the antinociceptive effect was reversed by the lectin-binding carbohydrate α-d-methyl-mannoside and by the nonselective opioid antagonist naloxone. The antinociceptive effect observed in the formalin test was inhibited by the δ-selective antagonist naltrindole and the κ-selective antagonist nor-binaltorphimine but not by the μ-selective antagonist cyprodime. In conclusion, when administered orally to Swiss mice, the ConBr lectin displayed antinociceptive activity, both peripheral and central, mediated by the opioid system and involving δ-and κ-receptors and the lectin domain.
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