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  • Title: Distinct behavioral consequences of stress models of depression in the elevated T-maze.
    Author: de Paula Soares V, Vicente MA, Biojone C, Zangrossi H, Guimarães FS, Joca SR.
    Journal: Behav Brain Res; 2011 Dec 01; 225(2):590-5. PubMed ID: 21896290.
    Abstract:
    Animals exposed to inescapable stress develop behavioral consequences that are similar to symptoms of depression. Therefore, most of the animal models of depression are based on animal exposure to such stressors. The stress-induced behavioral consequences induced by pre-exposure to shock in the learned helplessness model of depression have been proposed to be a consequence of excessive activation of fear/anxiety related structures which would lead to inhibitory avoidance and impaired escape performance. However, this hypothesis has not yet been investigated in a test that is able to generate these different defense strategies in a same rat, such as the elevated T-maze (ETM). Therefore, the objective of the present study was to test the effects of footshock pre-exposure (inescapable-IS or escapable-ES) on both inhibitory avoidance and escape responses of rats submitted to the ETM 24 h later. Moreover, since it is not known whether these effects would be a common feature to other inescapable stressors used as animal models of depression, we have also investigated the behavior of rats previously exposed to forced swimming or restraint. All stressed groups displayed anxiogenic-like behavior when compared to control groups (non-stressed), evidenced by facilitated acquisition of inhibitory avoidance in the ETM. However, only rats exposed to IS showed impaired escape performance. These results support the hypothesis that the facilitated inhibitory avoidance is a common behavioral consequence of distinct stressful stimuli. However, the impaired escape response is likely to be particularly involved in the mediation of the helpless behavior observed in rats pre-exposed to IS. The neurobiological mechanisms involved in these responses are discussed in the manuscript.
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