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  • Title: A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover.
    Author: Morris DL, Wilson SR, Pain J, Edwardson KF, Jones J, Strachan C, Slack R.
    Journal: J Antimicrob Chemother; 1990 Apr; 25(4):673-8. PubMed ID: 2190974.
    Abstract:
    Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.
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