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  • Title: Commercial double-indicator-dilution densitometer using heavy water: evaluation in oleic-acid pulmonary edema.
    Author: Leksell LG, Schreiner MS, Sylvestro A, Neufeld GR.
    Journal: J Clin Monit; 1990 Apr; 6(2):99-106. PubMed ID: 2191088.
    Abstract:
    We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L.min.m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.
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