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  • Title: Renal amyloidosis in a child with neutropenia.
    Author: Otukesh H, Hoseini R, Behzadi AH, Fereshtehnejad SM, Mehrazma M, Parvin M, Mojtahedzadeh M, Razizadeh N, Pourfakharan M.
    Journal: Saudi J Kidney Dis Transpl; 2011 Sep; 22(5):1019-21. PubMed ID: 21912038.
    Abstract:
    Amyloidosis represents a heterogeneous group of disorders of protein metabolism and is characterized by deposition of fibrillar proteins in the intra- and extracellular spaces. Here, a case of generalized amyloidosis associated with neutropenia is presented. She had a medical history of multiple bacterial infections. At the age of 14 years, she developed nephrotic syndrome. An increase of antigenic stimulation during the intermittent bouts of acute infections would have been the main factor responsible for the development of secondary amyloidosis in this case. To the best of our knowledge, coexistence between neutropenic disorders and renal amyloidosis in children has not been reported till date. The purpose of this report is to present a case of secondary amyloidosis associated with neutropenia in pediatric age group, probably for the first time.
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