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  • Title: [New aspects of the pathogenesis and therapy of Guillain-Barré syndrome and chronic polyneuritis].
    Author: Hartung HP, Heininger K, Toyka KV.
    Journal: Nervenarzt; 1990 Apr; 61(4):197-207. PubMed ID: 2191228.
    Abstract:
    The Guillain-Barré syndrome and chronic idiopathic polyradiculoneuropathy (CIDP) are examples of immune-mediated neuropathies. In the Guillain-Barré syndrome, antibodies directed to neutral glycolipids of peripheral nerve myelin have been detected that activate the complement system. There is evidence for the presence of circulating activated T lymphocytes. Humoral factors have been implicated in the pathogenesis of CIDP. The animal model experimental autoimmune neuritis lends itself to the elucidation of pathogenic immune mechanisms. The principal treatment is plasmapheresis. Further approaches to the therapy of the Guillain-Barré syndrome and CIDP are discussed.
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