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  • Title: [The effect of insulin on lethality in mice with acute ethanol poisoning].
    Author: Savitskaia EV, Listvina VP, Zabirova IG.
    Journal: Patol Fiziol Eksp Ter; 1990; (1):47-8. PubMed ID: 2191256.
    Abstract:
    Intraperitoneal injection of 25% ethanol solution in LD80 doses caused death of approximately 60% of satiated and starving animals in the first 60 minutes. The death peak was encountered 3-10 minutes after the injection of ethanol and corresponded with the peak of its concentration in the blood. The early death of the animals was connected with arrest of respiration in inhibition of cardiac activity. A tendency towards increase of ethanol LD50 60 minutes after its injection in administration of insulin was encountered. The changes of ethanol LD50 were statistically insignificant.
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