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  • Title: Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide.
    Author: Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC.
    Journal: J Exp Med; 1979 Apr 01; 149(4):969-74. PubMed ID: 219131.
    Abstract:
    The HL-60 human promyelocytic leukemia cell line can be induced to terminally differentiate to mature myeloid cells sharing a number of functional characteristics with normal granulocytes including response to chemoattractants, development of complement receptors, phagocytosis, superoxide production, and nitroblue tetrazolium dye reduction. Hence the Me2SO-induced HL-60 cells provide a unique in vitro model for studying various important aspects of human myeloid cell differentiation.
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