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  • Title: Propofol versus halothane in paediatric daycase surgery: a comparison of the duration of induction and haemodynamic profile.
    Author: Akintimoye MO, Desalu I, Kushimo OT.
    Journal: Nig Q J Hosp Med; 2011; 21(1):80-4. PubMed ID: 21913547.
    Abstract:
    BACKGROUND: Inhalational induction with Halothane is commonly used for anaesthesia in children. Its drawbacks include bradycardia and hypotension. Intravenous propofol has recently challenged this position. OBJECTIVE: This study sought to compare duration of and cardiovascular changes at induction of anaesthesia in children. METHODS: Sixty ASA I and II children aged 1- 7 years scheduled for elective daycase surgery were prospectively studied from January to July 2008. They were assigned to receive inhalational induction with halothane 3% or intravenous induction with 3.5mg/kg of propofol. Heart rate, systolic, diastolic and mean blood pressure as well as oxygen saturation were monitored throughout induction. The duration of induction as well as any complications were documented. RESULTS: Demographic data was comparable between the two groups. Duration of induction was significantly longer in the halothane group 8.23 +/- 2.34 minutes compared with 2.30 +/- 1.26 minutes in the propofol group (p < 0.001). Heart rate rose by 4.7 +/- 17.73 beats/minute in the propofol group and fell by 4.19 +/- 18.03 in the halothane group (p = 0.05). Systolic, diastolic and mean blood pressures fell in both groups with values being less in the halothane group. These differences were not significantly different (p = 0.189, p = 0.059, p = 0.058 respectively). Sixteen patients (33%) in the propofol group developed apnoea compared to 2 (6.6%) in the halothane group (p < 0.001). The duration of apnoea differed significantly between groups (p = 0.003). CONCLUSION: Halothane and propofol had similar changes to cardiovascular parameters during anaesthetic induction. The shorter duration of induction of propofol may be preferable for daycase surgeries.
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